A Systematic review comparing outcomes of laparoscopic and transvesicoscopic ureteroneocystostomy
Received: 2025-05-28
Published: 2025-03-30
Abstract
Background. We have examined and compared the results of the articles on LEVUR and TVUR in this systematic review and meta-analysis.
Materials and methods. To find all the studies about TVUR and LEVUR in the pediatric population, we examined the databases. Exclusions were review articles, unfinished articles, duplicate publica- tions, and robot-assisted publications. To determine patient information, reflux grades, laterality, length of operation, time to discharge, success rate, and complications, a systematic review was carried out.
Results. 23 articles -13 on TVUR and 10 on LEVUR - were included after a total of 45 articles were screened. In TVUR grade 5 VUR was substantially larger (11.9%, p = 0.001) than in LEVUR (2.2%). When comparing TVUR to LEVUR, the percentage of bilateral reimplantation was considerably higher (p = 0.001). 96.7% was the success rate of LEVUR, a considerable increase above TVUR 93.7% (p = 0.007). Unilateral/bilateral TVUR took significantly longer duration of surgery (155/194 min vs 107/161 min) compared to LEVUR (p = 0.001). The mean (s.d) time to discharge was longer at 3.2 (1.6) days for TVUR compared to 1.6 (0.4) days for LEVUR (p = 0.001). The complication rate was comparable, 7.35% for TVUR and 5.35% for LEVUR (p = 0.167).
Conclusion. With regard to success rates and side effects, LEVUR and TVUR appear to be reason- able substitutes for open ureteric reimplantation. Compared to TVUR, which was recommended for bilateral UR and grade 5 VUR patients, LEVUR was more preferable for unilateral, grades 1-4 cases, had higher success, and required a shorter hospital stay. Although the types of complications varied according to the procedure, there was no discernible difference in the complication rate between LEVUR and TVUR.
Keywords
List of references
-
Kirsch AJ, Arlen AM. Evolving surgical management of pediatric vesicoureteral reflux. Is open ureteric reimplantation still the ‘gold standard’? Int Braz J Urol 2020;46:314e21.
-
Wang H-HS, Tejwani R, Cannon GM, Gargollo PC, Wiener JS, Routh JC. Open versus minimally invasive ureteroneocystostomy: a population-level analysis. J Pedia Urol 2016 Aug;12(4):232. e1-232.e6.
-
Wang H-HS, Tejwani R, Cannon GM, Gargollo PC, Wiener JS, Routh JC. Open versus minimally invasive ureteroneocystostomy: a population-level analysis. J Pediatr Urol 2016 Aug;12(4):232. e1-232.e6.
-
Sahadev R, Spencer K, Srinivasan AK, Long CJ, Shukla AR. The robot-assisted extravesical anti-reflux surgery: how we overcame the learning curve. Front Pediatr 2019 Mar 29;7.
-
Chung MS, Han SW, Jung HJ, Im YJ, Han HH, Na JC, et al. Transvesicoscopic ureteral reimplantation in children with bilateral vesicoureteral reflux: surgical technique and results. J Laparoendosc Adv Surg Tech 2012 Apr;22(3):295e300.
-
Yeung CK, Sihoe JDY, Borzi PA. Endoscopic cross-trigonal ureteral reimplantation under carbon dioxide bladder insufflation: a novel technique. J Endourol 2005 Apr;19(3):295e9.
-
Kutikov A, Guzzo TJ, Canter DJ, Casale P. Initial experience with laparoscopic transvesical ureteral reimplantation at the children’s hospital of Philadelphia. J Urol 2006 Nov;176(5): 2222e6.
-
Valla JS, Steyaert H, Griffin SJ, Lauron J, Fragoso AC, Arnaud P, et al. Transvesicoscopic Cohen ureteric reimplantation for vesicoureteral reflux in children: a single-centre 5year experience. J Pediatr Urol 2009 Dec;5(6):466e71.
-
Jayanthi VR. Vesicoscopic cross-trigonal ureteral reimplantation: high success rate for elimination of primary reflux. J Pediatr Urol 2018 Aug;14(4):324. e1-324.e5.
-
Kawauchi A, Naitoh Y, Soh J, Hirahara N, Okihara K, Miki T. Transvesical laparoscopic cross-trigonal ureteral reimplantation for correction of vesicoureteral reflux: initial experience and comparisons between adult and pediatric cases. J Endourol 2009 Nov;23(11):1875. 8.
-
Emir H, Mammadov E, Elicevik M, Buyukunal C, Soylet Y. Transvesicoscopic cross-trigonal ureteroneo- cystostomy in children: a single-center experience. J Pediatr Urol 2012 Feb; 8(1):83e6.
-
Marte A, Sabatino M, Borrelli M, Nino F, Prezioso M, Pintozzi L, et al. Pneumovesicoscopic correction of primary vesicoureteral reflux (VUR) in children. Our experience. Eur J Pediatr Surg 2010 Nov 15;20(6):366e70.
-
Abraham MK, Viswanath N, Bindu S, Kedari P, Ramakrishnan P, Naaz A, et al. A simple and safe technique for trocar positioning in vesicoscopic ureteric reimplantation. Pediatr Surg Int 2011 Nov 19;27(11):1223e6.
-
Soh S, Kobori Y, Shin T, Suzuki K, Iwahata T, Sadaoka Y, et al. Transvesicoscopic ureteral reimplantation: PolitanoLeadbetter versus Cohen technique. Int J Urol 2015 Apr; 22(4):394e9. https://doi.org/10.1111/iju. 12702.
-
Ansari MS, Yadav P, Arora S, Singh P, Sekhon V. Bilateral transvesicoscopic cross-trigonal ureteric reimplantation in children: surgical subtleties and a prospective summary. Urology 2017 Mar;101:67e72.
-
Lau CT, Lan LCL, Wong KK, Tam PKH. Pneumovesical ureteric reimplantation in pediatric patients: an intermediate term result. J Laparoendosc Adv Surg Tech 2017 Feb;27(2):203e5.
-
Chung KLY, Sihoe J, Liu K, Chao N, Hung J, Liu C, et al. Surgical outcome analysis of pneumovesicoscopic ureteral reimplantation and endoscopic dextranomer/hyaluronic acid injection for primary vesicoureteral reflux in children: a multicenter 12year review. J Laparoendosc Adv Surg Tech 2018 Mar;28(3): 348e53.
-
Tsai YC, Wu CC, Yang SSD. Minilaparoscopic nerve-sparing extravesical ureteral reimplantation for pri- mary vesicoureteral reflux: a preliminary report. J Laparoendosc Adv Surg Tech 2008 Sep;18(5):767e70.
-
Riquelme M, Lopez M, Landa S, Mejia F, Aranda A, RodarteShade M, et al. Laparoscopic extravesical ureteral reimplantation (LEVUR): a multicenter experience with 95 cases. Eur J Pediatr Surg 2012 Nov 19;23(2):143e7.
-
Bayne AP, Shoss JM, Starke NR, Cisek LJ. Single-Center experience with pediatric laparoscopic extraves- ical reimplantation: safe and effective in simple and complex anatomy. J Laparoendosc Adv Surg Tech 2012 Jan;22(1):102e6.
-
Javali T, Pathade A, Nagaraj HK. Laparoscopic extravesical detrusorraphy, a minimally invasive treatment option for vesicoureteral reflux: a single centre experience. J Pediatr Urol 2015 Apr;11(2):88. e1-88.e6.
-
Esposito C, Escolino M, Lopez M, Farina A, Cerulo M, Savanelli A, et al. Surgical management of pediatric vesicoureteral reflux: a comparative study between endoscopic, laparoscopic, and open surgery. J Laparoendosc Adv Surg Tech 2016 Jul;26(7):574e80.
-
Soulier V, Scalabre A, Lopez M, Li C-Y, Thach S, Vermersch S, et al. Laparoscopic vesico-ureteral reimplantation with LicheGregoir approach in children: medium term results of 159 renal units in 117 children. World J Urol 2017 Nov 21; 35(11):1791e8.
-
Badawy HE, Refaai K, Soliman AS, Orabi SS. Laparoscopic reimplantation of refluxing ureter in children: a feasibility study. Arab J Urol 2017 Mar 18;15(1):48e52.
-
Bustangi N, Kallas Chemaly A, Scalabre A, Khelif K, Luyckx S, Steyaert H, et al. Extravesical ureteral reimplantation following Lich-Gregoir technique for the correction of vesicoureteral reflux retrospective comparative study open vs. Laparoscopy. Front Pediatr 2018 Dec 18;6.
-
Capolicchio J-P. Laparoscopic extravesical ureteral reimplantation: technique. Adv Urol 2008;2008:1e5.
-
Lopez M, Varlet F. Laparoscopic extravesical transperitoneal approach following the Lich-Gregoir tech- nique in the treatment of vesicoureteral reflux in children. J Pediatr Surg 2010 Apr;45(4):806e10.
-
Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications. Ann Surg 2009 Aug;250(2):187e96.
-
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009 Dec 4;339(jul21 1):b2700. b2700.
-
Hubert KC, Kokorowski PJ, Huang L, Prasad MM, Rosoklija I, Retik AB, et al. Clinical outcomes and long-term resolution in patients with persistent vesicoureteral reflux after open ureteral reimplantation. J Urol 2012 Oct;188(4S):1474e9.
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