Vol. 4 No. 1 (2026): January-March
23-31
2026-03-30
Open Access

Comparative analysis of the effects of propofol and sevoflurane anesthesia on intraoperative metabolic, electrolyte, and acid–base homeostasis in children undergoing craniotomy for brain tumors

E.A. Satvaldieva
A.A. Abdukadirov
B.F. Khodzhiev
K.I. Khaydarov
A.S. Abipnazarova
https://doi.org/10.63417/

Received: 2026-10-03

Published: 2026-03-30

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Abstract

Background: The primary anesthetic technique used for craniotomy in children with brain tumors may influence metabolic, electrolyte, and acid–base homeostasis and the early postoperative course.


Objective: To compare these changes during propofol- and sevoflurane-based anesthesia and assess their relationship with early complications.


Materials and Methods: A retrospective comparative analysis included 99 children: 51 received propofol and 48 sevoflurane. Before anesthesia, after intubation, and at the end of surgery, pH, pCO2, pO2, SBE, ABE, HCO3-, hemoglobin, hematocrit, K+, Na+, Ca2+, Cl-, glucose, and lactate were assessed.


Results: The sevoflurane group had higher Na+ after intubation and at the end of surgery, higher K+ after intubation, and higher end-of-surgery lactate (1.04±0.34 vs 0.86±0.21 mmol/L; p=0.0005). Drowsiness (16.7% vs 2.0%; p=0.028) and nausea (22.9% vs 3.9%; p=0.013) were more frequent. Acid–base parameters did not differ significantly between groups.


Conclusions: Sevoflurane-based anesthesia was associated with more pronounced electrolyte and lactate shifts and a higher frequency of selected early postoperative complications.

Keywords

List of references

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About the Authors

E.A. Satvaldieva
info@hnchmc.uz
A.A. Abdukadirov
info@hnchmc.uz
B.F. Khodzhiev
info@hnchmc.uz
K.I. Khaydarov
info@hnchmc.uz
A.S. Abipnazarova
info@hnchmc.uz

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How to Cite

Comparative analysis of the effects of propofol and sevoflurane anesthesia on intraoperative metabolic, electrolyte, and acid–base homeostasis in children undergoing craniotomy for brain tumors. (2026). Herald of the National Children’s Medical Center, 4(1), 23-31. https://doi.org/10.63417/

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