MULTIDISCIPLINARY APPROACH TO THE CONSERVATIVE TREATMENT OF CHILDREN WITH OSTEOGENESIS IMPERFECTA AT THE NATIONAL CHILDREN’S MEDICAL CENTER
Received: 2025-05-18
Published: 2025-05-03
Abstract
Osteogenesis imperfecta (ICD-10 Q78.0) is a hereditary connective tissue disorder characterized by bone fragility, multiple fractures, and skeletal deformities. In 85–90% of cases, mutations are found in the COL1A1 and COL1A2 genes. The disease may follow autosomal dominant, autosomal recessive, or X-linked patterns of inheritance. Its prevalence is estimated at 1 in 10,000 to 1 in 20,000 live births. The modern classification includes 18 types of the disease according to Sillence.
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MULTIDISCIPLINARY APPROACH TO THE CONSERVATIVE TREATMENT OF CHILDREN WITH OSTEOGENESIS IMPERFECTA AT THE NATIONAL CHILDREN’S MEDICAL CENTER. (2025). Herald of the National Children’s Medical Center, 137-139. https://hnchmc.uz/jour/article/view/179