A Systematic review comparing outcomes of laparoscopic and transvesicoscopic ureteroneocystostomy
Abstract
Background. We have examined and compared the results of the articles on LEVUR and TVUR in this systematic review and meta-analysis.
Materials and methods. To find all the studies about TVUR and LEVUR in the pediatric population, we examined the databases. Exclusions were review articles, unfinished articles, duplicate publica- tions, and robot-assisted publications. To determine patient information, reflux grades, laterality, length of operation, time to discharge, success rate, and complications, a systematic review was carried out.
Results. 23 articles -13 on TVUR and 10 on LEVUR - were included after a total of 45 articles were screened. In TVUR grade 5 VUR was substantially larger (11.9%, p = 0.001) than in LEVUR (2.2%). When comparing TVUR to LEVUR, the percentage of bilateral reimplantation was considerably higher (p = 0.001). 96.7% was the success rate of LEVUR, a considerable increase above TVUR 93.7% (p = 0.007). Unilateral/bilateral TVUR took significantly longer duration of surgery (155/194 min vs 107/161 min) compared to LEVUR (p = 0.001). The mean (s.d) time to discharge was longer at 3.2 (1.6) days for TVUR compared to 1.6 (0.4) days for LEVUR (p = 0.001). The complication rate was comparable, 7.35% for TVUR and 5.35% for LEVUR (p = 0.167).
Conclusion. With regard to success rates and side effects, LEVUR and TVUR appear to be reason- able substitutes for open ureteric reimplantation. Compared to TVUR, which was recommended for bilateral UR and grade 5 VUR patients, LEVUR was more preferable for unilateral, grades 1-4 cases, had higher success, and required a shorter hospital stay. Although the types of complications varied according to the procedure, there was no discernible difference in the complication rate between LEVUR and TVUR.
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List of references
Kirsch AJ, Arlen AM. Evolving surgical management of pediatric vesicoureteral reflux. Is open ureteric reimplantation still the ‘gold standard’? Int Braz J Urol 2020;46:314e21.
Wang H-HS, Tejwani R, Cannon GM, Gargollo PC, Wiener JS, Routh JC. Open versus minimally invasive ureteroneocystostomy: a population-level analysis. J Pedia Urol 2016 Aug;12(4):232. e1-232.e6.
Wang H-HS, Tejwani R, Cannon GM, Gargollo PC, Wiener JS, Routh JC. Open versus minimally invasive ureteroneocystostomy: a population-level analysis. J Pediatr Urol 2016 Aug;12(4):232. e1-232.e6.
Sahadev R, Spencer K, Srinivasan AK, Long CJ, Shukla AR. The robot-assisted extravesical anti-reflux surgery: how we overcame the learning curve. Front Pediatr 2019 Mar 29;7.
Chung MS, Han SW, Jung HJ, Im YJ, Han HH, Na JC, et al. Transvesicoscopic ureteral reimplantation in children with bilateral vesicoureteral reflux: surgical technique and results. J Laparoendosc Adv Surg Tech 2012 Apr;22(3):295e300.
Yeung CK, Sihoe JDY, Borzi PA. Endoscopic cross-trigonal ureteral reimplantation under carbon dioxide bladder insufflation: a novel technique. J Endourol 2005 Apr;19(3):295e9.
Kutikov A, Guzzo TJ, Canter DJ, Casale P. Initial experience with laparoscopic transvesical ureteral reimplantation at the children’s hospital of Philadelphia. J Urol 2006 Nov;176(5): 2222e6.
Valla JS, Steyaert H, Griffin SJ, Lauron J, Fragoso AC, Arnaud P, et al. Transvesicoscopic Cohen ureteric reimplantation for vesicoureteral reflux in children: a single-centre 5year experience. J Pediatr Urol 2009 Dec;5(6):466e71.
Jayanthi VR. Vesicoscopic cross-trigonal ureteral reimplantation: high success rate for elimination of primary reflux. J Pediatr Urol 2018 Aug;14(4):324. e1-324.e5.
Kawauchi A, Naitoh Y, Soh J, Hirahara N, Okihara K, Miki T. Transvesical laparoscopic cross-trigonal ureteral reimplantation for correction of vesicoureteral reflux: initial experience and comparisons between adult and pediatric cases. J Endourol 2009 Nov;23(11):1875. 8.
Emir H, Mammadov E, Elicevik M, Buyukunal C, Soylet Y. Transvesicoscopic cross-trigonal ureteroneo- cystostomy in children: a single-center experience. J Pediatr Urol 2012 Feb; 8(1):83e6.
Marte A, Sabatino M, Borrelli M, Nino F, Prezioso M, Pintozzi L, et al. Pneumovesicoscopic correction of primary vesicoureteral reflux (VUR) in children. Our experience. Eur J Pediatr Surg 2010 Nov 15;20(6):366e70.
Abraham MK, Viswanath N, Bindu S, Kedari P, Ramakrishnan P, Naaz A, et al. A simple and safe technique for trocar positioning in vesicoscopic ureteric reimplantation. Pediatr Surg Int 2011 Nov 19;27(11):1223e6.
Soh S, Kobori Y, Shin T, Suzuki K, Iwahata T, Sadaoka Y, et al. Transvesicoscopic ureteral reimplantation: PolitanoLeadbetter versus Cohen technique. Int J Urol 2015 Apr; 22(4):394e9. https://doi.org/10.1111/iju. 12702.
Ansari MS, Yadav P, Arora S, Singh P, Sekhon V. Bilateral transvesicoscopic cross-trigonal ureteric reimplantation in children: surgical subtleties and a prospective summary. Urology 2017 Mar;101:67e72.
Lau CT, Lan LCL, Wong KK, Tam PKH. Pneumovesical ureteric reimplantation in pediatric patients: an intermediate term result. J Laparoendosc Adv Surg Tech 2017 Feb;27(2):203e5.
Chung KLY, Sihoe J, Liu K, Chao N, Hung J, Liu C, et al. Surgical outcome analysis of pneumovesicoscopic ureteral reimplantation and endoscopic dextranomer/hyaluronic acid injection for primary vesicoureteral reflux in children: a multicenter 12year review. J Laparoendosc Adv Surg Tech 2018 Mar;28(3): 348e53.
Tsai YC, Wu CC, Yang SSD. Minilaparoscopic nerve-sparing extravesical ureteral reimplantation for pri- mary vesicoureteral reflux: a preliminary report. J Laparoendosc Adv Surg Tech 2008 Sep;18(5):767e70.
Riquelme M, Lopez M, Landa S, Mejia F, Aranda A, RodarteShade M, et al. Laparoscopic extravesical ureteral reimplantation (LEVUR): a multicenter experience with 95 cases. Eur J Pediatr Surg 2012 Nov 19;23(2):143e7.
Bayne AP, Shoss JM, Starke NR, Cisek LJ. Single-Center experience with pediatric laparoscopic extraves- ical reimplantation: safe and effective in simple and complex anatomy. J Laparoendosc Adv Surg Tech 2012 Jan;22(1):102e6.
Javali T, Pathade A, Nagaraj HK. Laparoscopic extravesical detrusorraphy, a minimally invasive treatment option for vesicoureteral reflux: a single centre experience. J Pediatr Urol 2015 Apr;11(2):88. e1-88.e6.
Esposito C, Escolino M, Lopez M, Farina A, Cerulo M, Savanelli A, et al. Surgical management of pediatric vesicoureteral reflux: a comparative study between endoscopic, laparoscopic, and open surgery. J Laparoendosc Adv Surg Tech 2016 Jul;26(7):574e80.
Soulier V, Scalabre A, Lopez M, Li C-Y, Thach S, Vermersch S, et al. Laparoscopic vesico-ureteral reimplantation with LicheGregoir approach in children: medium term results of 159 renal units in 117 children. World J Urol 2017 Nov 21; 35(11):1791e8.
Badawy HE, Refaai K, Soliman AS, Orabi SS. Laparoscopic reimplantation of refluxing ureter in children: a feasibility study. Arab J Urol 2017 Mar 18;15(1):48e52.
Bustangi N, Kallas Chemaly A, Scalabre A, Khelif K, Luyckx S, Steyaert H, et al. Extravesical ureteral reimplantation following Lich-Gregoir technique for the correction of vesicoureteral reflux retrospective comparative study open vs. Laparoscopy. Front Pediatr 2018 Dec 18;6.
Capolicchio J-P. Laparoscopic extravesical ureteral reimplantation: technique. Adv Urol 2008;2008:1e5.
Lopez M, Varlet F. Laparoscopic extravesical transperitoneal approach following the Lich-Gregoir tech- nique in the treatment of vesicoureteral reflux in children. J Pediatr Surg 2010 Apr;45(4):806e10.
Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications. Ann Surg 2009 Aug;250(2):187e96.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009 Dec 4;339(jul21 1):b2700. b2700.
Hubert KC, Kokorowski PJ, Huang L, Prasad MM, Rosoklija I, Retik AB, et al. Clinical outcomes and long-term resolution in patients with persistent vesicoureteral reflux after open ureteral reimplantation. J Urol 2012 Oct;188(4S):1474e9.
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