FREQUENCY OF INCIDENCE AND RISK FACTORS FOR DEVELOPMENT OF CONGENITAL HEART DISEASES IN CHILDREN OF KHOREZM RE¬GION OF THE REPUBLIC OF UZBEKISTAN
Abstract
Currently, congenital pathology of the heart and great vessels, which is the root cause of early disability and death of children, especially the first year of life, is becoming increasingly important. The article presents the results of a retrospective analysis of outpatient cards for 64 children born with congenital heart defects for the period 2019-2020. in the Khorezm region of the Republic of Uzbekistan. The most common heart defect in children is the ventricular septal defect. The highest frequency of congenital malformations was registered in Khozarasp (21.9%) and Yangiarik (18.8%) districts, the lowest in Yangibazar district (1.6%) of Khorezm region. Complicated obstetric history of mothers of children born with congenital heart defects, as well as acute viral diseases in the first trimester of pregnancy and laboratory confirmed carriage of high Ig G titers to such TORCH infections as herpes, toxoplasmosis and cytomegalovirus, probably influenced the formation of congenital heart defects in children.
Keywords:
About the Authors
List of references
Саперова Е.В., Вахлова И.В. Врожденные пороки сердца у детей: распространенность, факторы риска, смертность. Вопросы современной педиатрии, 2017. -Т. 16 -№ 2. -С. 126-133. doi: 10.15690/vsp.v16i2.1713
Glinianaia S.V., Morris J.K., Best K.E., Santoro M., Coi A., Armaroli A., et al. Long-term survival of children born with congenital anomalies: A systematic review and meta-analysis of population-based studies. PLoS Med. 2020. -Vol. 17. -№9. -P. e1003356. https://doi.org/10.1371/ journal.pmed.1003356
Jenkins K.J., Correa A., Feinstein J.A., et al. Noninherited risk factors and congenital cardiovascular defects: cur¬rent knowledge: a scientific statement from the Ameri¬can Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pe¬diatrics. Circulation, 2007. -Vol. 115 -№23. -P. 2995-3014. doi: 10.1161/ CIRCULATIONAHA.106.183216
Bu H., Gong X., Zhao T. Image diagnosis: Eisenmenger's syndrome in patients with simple congenital heart dis¬ease. BMC Cardiovascular Disorders, 2020. -Vol. 20. -№1.-P. 194. DOI:10.1186/s12872-020- 01489-y
Бениова С.Н., Фиголь С.Ю., Корнилова О.А., Столина М.Л., Блохина Н.П. Клинико-патогенетические осо¬бенности врождённых пороков сердца у новоро¬ждённых с внутриутробной инфекцией. Казанский медицинский журнал, 2017. -Т. 98. №2. -С. 181-188. doi: 10.17750/KMJ2017-181
Миролюбов Л.М., Петрушенко Д.Ю., Калиничева Ю.Б., Сабирова Д.Р. Диагностика и лечение врождённых пороков сердца у новорождённых. Казанский ме¬дицинский журнал, 2015. -Т. 96. -№4. -С. 628-632. doi: 10.17750/KMJ2015-628
Botto L, Panichello JD, Browne ML, et al. Congenital heart defects after maternal fever. Am J Obstetrics Gynecology, 2014. -Vol. 210 №4. -P. 359. doi: 10.1016/j.ajog.2013.10.880
Glinianaia S.V, Morris J.K, Best K.E, Santoro M, Coi A, Armaroli A, et al. Long-term survival of children born with congenital anomalies: A systematic review and me¬ta-analysis of population-based studies. PLoSMed, 2020. -Vol. 17. -№9. e1003356. https://doi.org/10.1371/journal. pmed.1003356