Bosh miya o‘smalari sababli kraniotomiya o‘tkazilgan bolalarda propofol va sevofluran anesteziyasining intraoperatsion metabolik, elektrolit va kislota-asos gomeostaziga ta’sirini qiyosiy tahlil qilish
Qabul qilingan: 2026-10-03
Nashr etilgan: 2026-03-30
Annotatsiya
Dolzarbligi. Bosh miya o‘smalari sababli kraniotomiya o‘tkaziladigan bolalarda qo‘llaniladigan asosiy anesteziya usuli metabolik, elektrolit va kislota-asos gomeostaziga, shuningdek, erta operatsiyadan keyingi davr kechishiga ta’sir qilishi mumkin.
Maqsad. Propofol va sevofluran asosidagi anesteziya vaqtida ushbu ko‘rsatkichlardagi o‘zgarishlarni qiyoslash hamda ularning erta operatsiyadan keyingi asoratlar bilan bog‘liqligini baholash.
Materiallar va usullar. Retrospektiv qiyosiy tahlilga 99 nafar bola kiritildi: 51 nafar bemorda propofol, 48 nafarida sevofluran qo‘llanildi. Anesteziyadan oldin, intubatsiyadan keyin va operatsiya yakunida pH, pCO₂, pO₂, SBE, ABE, HCO₃⁻, gemoglobin, gematokrit, K⁺, Na⁺, Ca²⁺, Cl⁻, glyukoza va laktat ko‘rsatkichlari baholandi.
Natijalar. Sevofluran guruhida intubatsiyadan keyin va operatsiya yakunida Na⁺ darajasi, intubatsiyadan keyin K⁺ darajasi, shuningdek, operatsiya yakunida laktat miqdori yuqoriroq bo‘ldi (1,04±0,34 ga nisbatan 0,86±0,21 mmol/l; p=0,0005). Uyquchanlik (16,7% ga nisbatan 2,0%; p=0,028) va ko‘ngil aynishi (22,9% ga nisbatan 3,9%; p=0,013) ko‘proq kuzatildi. Kislota-asos holati ko‘rsatkichlari bo‘yicha guruhlar o‘rtasida statistik jihatdan ahamiyatli farqlar aniqlanmadi.
Xulosa. Sevofluran asosidagi anesteziya elektrolitlar va laktat darajasidagi yaqqolroq o‘zgarishlar hamda ayrim erta operatsiyadan keyingi asoratlarning yuqoriroq chastotasi bilan bog‘liq bo‘ldi.
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