TUG‘MA YURAK NUQSONLARI BO‘LGAN BOLALARDA IL-1β VA IL-33 NING KLINIK-DIAGNOSTIK AHAMIYATI HAMDA ULARNING MIOKARDIAL STRESS BIOMARKERLARI NT-proBNP VA sST2 BILAN BOG‘LIQLIGI
Qabul qilingan: 2026-10-03
Nashr etilgan: 2026-03-30
Annotatsiya
Dolzarbligi. Tug‘ma yurak nuqsonlari (TYuN) tizimli yallig‘lanish va miokardial stress bilan kechadi, bu esa informativ biomarkerlardan foydalanish zaruratini ko‘rsatadi.
Maqsad. TYuN bo‘lgan bolalarda IL-1β va IL-33 ning diagnostik ahamiyatini hamda ularning NT-proBNP va sST2 bilan bog‘liqligini aniqlash.
Materiallar va usullar. 2024–2026-yillarda 232 nafar bola tekshirildi: 202 nafar TYuNli bemor, jumladan 92 nafar sianotik va 110 nafar asianotik nuqsonli bola hamda 30 nafar shartli sog‘lom nazorat guruhi. IL-1β va IL-33 darajalari ELISA usulida, NT-proBNP immunoxemilyuminessent usulda, sST2 esa ELISA usulida aniqlandi.
Natijalar. IL-1β darajasi nazorat guruhida 2,9±0,4 pg/ml, sianotik TYuNda 23,7±4,8 pg/ml va asianotik TYuNda 16,3±2,6 pg/ml ni tashkil etdi. IL-33 darajalari mos ravishda 2,3±0,3, 19,2±3,6 va 14,5±2,2 pg/ml bo‘ldi. Sitokinlar darajasi bilan NT-proBNP/sST2 o‘rtasida musbat bog‘liqliklar aniqlandi; modifikatsiyalangan ultrafiltratsiya qo‘llanilganda o‘rganilgan markerlarning operatsiyadan keyingi pasayishi yanada yaqqol bo‘ldi.
Xulosa. IL-1β va IL-33 ni NT-proBNP va sST2 bilan birgalikda qo‘llash TYuNli bolalarda yallig‘lanish faolligi va miokardial stressni kompleks baholashga yordam berishi mumkin.
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